Orion-Yhtyma Oy

Thomas Yorio

Arto J Karjalainen

Risto A Lammintausta

Arto Olavi Urtti

Raimo E Virtanen

Ewen MacDonald

Compounds of formula: ##STR1## where X is --CH.sub.2 --, --CH(CH.sub.3)--, --CHR.sub.3 --CH.sub.2 -- or --CR.sub.3 .dbd.CH-- and R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, are each H or CH.sub.3 or a stereoisomer or pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing them, are useful for lowering intraocular pressure in a mammal, e.g. in the treatment of glaucoma.

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Burleson, TX, United States of America

Thomas Yorio