Research, Incorporated

Thomas X Neenan

Harry R Allcock

Paul E Austin

Walter C Kossa

A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and certain radicals having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitrogen single bond is disclosed along with medicaments containing such anesthetics. The radicals employed are 2-amino-4-picoline, benoxinate, naepaine and phenacaine.

Anesthetic polyorganophosphazenes

A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and 2-amino-4-picoline radical having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitrogen single bond is disclosed along with medicaments containing such anesthetics.

A polyphosphazene-bound heparin complex comprising a polymeric phosphozine backbone, a quaternary ammonium ion covalently attached to the backbone through a bivalent organic radical attached at one end to the nitrogen atoms of the ion and at the other end to a phosphorus atoms of the backbone, and heparin ionically bound to said quaternary ammonium ion is disclosed along with methods for preparing such complexes.

Heparinized polyorganophosphazenes

A carboxylated phosphazene polymer, comprising a phosphazene polymer backbone covalently coupled to a carboxylate-containing compound through a divalent organic radical attached at one end to the carboxylate by an amide bond formed at a primary aliphatic amino group of the radical and at the other end to a phosphorous of the phosphazene backbone.

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State College, PA, United States of America

Thomas X Neenan