Smithkline Beecham Corporation

Smithkline Beckman Corporation

Thomas Wen-Fu Ku

William Edward Bondinell

John G Gleason

Ralph F Hall

Richard McCulloch Keenan

James Francis Callahan

Kenneth Allen Newlander

William F Huffman

James Martin Samanen

Carl D Perchonock

William Henry Miller

Fadia E Ali

Joseph W Venslavsky

Robert M DeMarinis

Irene Nijole Uzinskas

Francis R Pfeiffer

Michael J Neeb

Dinubhai H Shah

Herbert S Ormsbee, Iii

Tobias Oregon Yellin

Raul Rolando Calvo

Bicyclic fibrinogen antagonists

This invention relates to substituted heteroanilide compounds which are modulators, agonists or antagonists, of the CCR5 receptior. In addition, this invention relates to the treatment and prevention of disease states mediatd by CCR5.

Compounds and methods

Vitronectin receptor antagonist

Vitronectin receptor antagonists

Compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form a seven-membered ring containing one optionally substituted nitrogen atom and one heteroatom selected from oxygen and nitrogen;

This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.

Fibrinogen receptor antagonists

Compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form a seven-membered ring containing one optionally substituted nitrogen atom;

Alpha-adrenergic receptor antagonsists having the formula (I) as set forth below which are useful to produce alpha-adrenergic antagonism, pharmaceutical compositions thereof, and methods of treatment therewith are disclosed: ##STR1## The variables X, R, Y, Het and A are as defined in the specification.

Furo- and thieno[4,3,2-ef][3]benzazepines useful as alpha adrenergic

Alpha-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonists to produce .alpha.-adrenoceptor antagonism in mammals.

Alpha-adrenergic receptor antagonists

This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Leukotriene antagonists

This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

Thiophenyl Alkanoic acids useful as leukotriene antagonists

Growing community of inventors

Dresher, PA, United States of America

Thomas Wen-Fu Ku