Hoffmann-La Roche Inc.

Actelion Pharmaceuticals Ltd

Other

F. Hoffmann-La Roche Ag

Thomas Weller

Leo Alig

Martine Clozel

Walter Fischli

Martin Bolli

Marcel Muller

Albrecht Edenhofer

Christoph Boss

Thierry Sifferlen

Hamed Aissaoui

Claus Mueller

Boris Mathys

Johannes Aebi

Jean Ackermann

Henrietta Dehmlow

Oliver Nayler

Beat Steiner

Paul Hadvary

Daniel Bur

Alexander Chucholowski

Olivier Morand

Arnold Trzeciak

Ralf Koberstein

Sabine Wallbaum

Kurt Hilpert

Sylvia Richard-Bildstein

David Lehmann

Lubos Remen

Olivier Bezencon

Michael Scherz

Marianne Hurzeler

Olivier Corminboeuf

Narendra Panday

Corinna Grisostomi

Jörg Velker

Michel Therien

Daniel Dube

Hans-Peter Maerki

Christoph Binkert

Rene Trussardi

Denise Blum

Marianne Hurzeler Muller

Elisabeth Von Der Mark

John Scheigetz

Dan McKay

Dwight MacDonald

Marcel M Uller

Austin Chih-Yu Chen

Judith Marfurt

J&ouml;rg Velker

Hans-Peter Weber

Joerg Velker

J)org Velker

David Powell

Marianne H Urzeler

Walter Fiśchli

Walter Actelion Pharmaceuticals Ltd Fischli

Sylvia Richard

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. 

Bicyclononene derivatives

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

Hydrogenated benzo (C) thiophene derivatives as immunomodulators

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

Secondary amines as renin inhibitors

The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative of formula (I), enantiomers thereof, and their use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I): or (I'): and especially their use as inhibitors of renin.

Diazabicyclononene derivatives and use thereof

The invention relates to novel sulfamic acid amides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.

Sulfamides as endothelin receptor antagonists for the treatment of cardiovascular diseases

Thiophene derivatives as spingosine-1-phosphate-1 receptor agonists

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.

Piperidine carboxylic acid amide derivatives

The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.

Substituted 1,2,3,4-tetrahydroisoquinoline derivatives

The invention relates to novel pyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

Pyridine derivatives

Thiophene derivatives

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds particularly as immunosuppressant agents.

Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists

The invention relates to quinoxalinone derivatives of general Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists. General Formula (I) wherein X and R-Rare as defined in the description 

Quinoxalin-3-one derivatives as orexin receptor antagonists

The invention relates to novel sulfamic acid amides of General Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists. 

Pyrimidine-sulfamides and their use as endothelian receptor antagonist

The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

Sulfonylamino-acetic acid derivatives

Growing community of inventors

Binningen, Switzerland

Thomas Weller