Sangamo Therapeutics, Inc.

Sigma-aldrich Co. LLC

University of Minnesota

Thomas Wechsler

Edward J Rebar

Jeffrey C Miller

Michael C Holmes

David Paschon

Lei Zhang

Gregory J Cost

Fuqiang Chen

Russell DeKelver

Gary K Lee

R Scott McIvor

Brigit E Riley

Susan J St Martin

Qiaohua Kang

Li Ou

Kanut Laoharawee

Chester B Whitley

Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.

Method of making and using mammalian liver cells for treating hemophilia or lysosomal storage disorder

Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.

Methods and compositions for genome engineering

Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease or a hemophilia by administering one or more topoisomerases inhibitors, one or more stabilizers of R loop formation or inhibitors of R-loop repair and/or one or more up-regulators of the TC-NER pathway to the target cell.

Methods and compositions for enhancing targeted transgene integration

The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.

Delivery methods and compositions for nuclease-mediated genome engineering

Method of treating factor IX deficiency using nuclease-mediated targeted integration

Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.

Methods and compositions for enhancing nuclease-mediated gene disruption

Growing community of inventors

Richmond, CA, United States of America

Thomas Wechsler