Ludwig Institute for Cancer Research Limited

Thomas W&ouml;lfel

Thierry R Boon-Falleur

Pierre G Coulie

Etienne De Plaen

Aline Van Pel

Vincent Brichard

Jean-Christope Renauld

Catia Traversari

Bernard Lethe

Bernard Leth&eacute;

The invention relates to complexes of human leukocyte antigen molecules and tyrosinase derived peptides SEQ ID NO: 2, on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.

METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HUMAN LEUKOCYTE ANTIGEN TYROSINASE DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS

The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The diagnostic ramifications of this observation are the subject of the invention.

Method of identifying individuals suffering from a cellular abnormality some of whose abnormal cells present complexes of human leukocyte antigen/tyrosinase derived peptides, and methods for treating said individuals

The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or 'TRAP&rdquo;, is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.

Methods for treating subjects with disorders characterized by expression of tumor rejection antigen precursors

Growing community of inventors

Mainz, Germany

Thomas Wölfel

Growing community of inventors

Mainz, Germany

Thomas W&ouml;lfel

Thomas Wölfel