Clinical Micro Sensors, Inc.

Molecular Dynamics Limited

Osmetech Technology, Inc.

Clinical Micro Systems, Inc.

Thomas W Welch

Thomas J Meade

Scott E Fraser

Jost G Vielmetter

Bruce D Irvine

Gary Fife Blackburn

Robert H Terbrueggen

Stephen E Creager

Stephen D O'Connor

Stephen J O'Connor

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

Binding acceleration techniques for the detection of analytes

Printed circuit boards with monolayers and capture ligands

The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Nucleosides comprising polydentate ligands

Growing community of inventors

Pasadena, CA, United States of America

Thomas W Welch