Oriel Therapeutics, Inc.

Thomas W Ruckdeschel

Scott Alexander Lewis

Jonathan David Tuckwell

Andrew Murray Gow

David Stuart Harris

Rachel Striebig

Matthew Allen

Charles Buckner

Cyan Godfrey

Margaret F Butler

Charles A Buckner, Iii

Andrew J Valentine

Daniel Deaton

James Grant Skakoon

Jerome A Grunstad

David A Schuelke

Gerald A Thoe

Jerome A Gruntad

Charles A Buckner

A Charles Buckner Iii

LEWIS;Scott Alexander

Methods of fabricating and operating dry powder inhalers that include dose disks and airway channel disks with sealant layers, the airway channel disks forming radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Dry powder dose container assemblies and related inhalers

A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Dry powder inhalers with dual piercing members and methods of operating same

Methods of operating and fabricating inhalers with airway disks having discrete airway channels

Dry powder inhaler

Dry powder inhalers with dual piercing members

Inhalers with an inhaler housing having a dose container disk having inner and outer perimeters mounted in the housing. The dose container disk has a plurality of circumferentially spaced apart dose containers with dry powder therein. The inhalers also include a piercer carriage with a piercer mounted in the inhaler. The piercer carriage is in communication with a resilient member that radially biases the piercer carriage to radially travel to align the piercer with an underlying or overlying dose container.

Inhaler mechanisms with radially biased piercers and related methods

Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.

Inhalers with airway disks having discrete airway channels and related disks and methods

Dose disk for a dry powder inhaler

Dry powder inhalers with dual piercing members and related devices and methods

Dose disk for dry powder inhalers

Growing community of inventors

Cary, NC, United States of America

Thomas W Ruckdeschel