Lever Brothers Company

Thomas W Ritchey

Martin Sapone

John M Weaver

Erwin Sharpe

A topically and systemically administered anti-inflammatory composition for human and for veterinary consumption which comprises compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hydrocarbon attachments and Y is --OH or a phenolic ester group derived from the reaction of such --OH group with a carboxylic acid halide or anhydride. In typical compounds covered by said general formula

Method of relieving pain and inflammatory conditions employing

A topically and systemically administered anti-inflammatory composition for human and for veterinary consumption which comprises compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hydrocarbon attachments and Y is --OH or a phenolic ester group derived from the reaction of such --OH group with a carboxylic acid halide or anhyride. In typical compounds covered by said general formula

A composition and method for retarding plaque are disclosed. The composition comprises a mixture of a zinc salt with a non-ring halogenated aromatic salicylamide of a specified structure.

Oral compositions of salicylamides and zinc salts for the synergistic

The astringency of an oral composition containing biologically active zinc ions may be reduced by the addition of glycine to the composition, and adjustment of the pH to about 4.5 to 9.4. In addition, zinc may be kept in a biologically active solution at this pH by the addition of glycine. The zinc-glycine combination serves as an anticalculus-antiplaque-antimalodor agent in oral compositions.

Oral compositions

The astringency of an oral composition containing biologically active zinc ions may be reduced by the addition of glycine to the composition, and adjustment of the pH to 4.5 to 8. In addition, zinc ions may be kept in a biologically active solution at this pH by the addition of glycine. The zinc-glycine combination serves as an anticalculus-antiplaque agent in oral compositions.

The astringency of an oral mouthwash composition containing biologically active zinc ions may be reduced by the addition of glycine to the composition, and adjustment of the pH to 4.5 to 8. In addition, zinc ions may be kept in a biologically active solution at this pH by the addition of glycine. The zinc-glycine combination serves as an anticalculus-antiplaque agent in oral compositions.

Oral mouthwash containing zinc and glycine

A method and a composition for retarding calculus are disclosed. The composition includes aluminum compounds, which when titrated with NaF have an F/Al ratio of about 1.2 or greater, in combination with an orally acceptable vehicle. The vehicle is compatible with the aluminum compound used and with the pH desired. The method generally includes applying the aluminum compound at a pH of less than about 4.5 to the site of the calculus.

Aluminum compounds as anti-calculus agents

A method and a composition for retarding plaque are disclosed. The composition includes a synergistic mixture of tetradecylamine in combination with copper, iron, nickel and/or cobalt, each of which may be used singly or in admixture in combination with the amine. The method generally includes applying a mixture of the tetradecylamine in combination with one or more of the above metals to the site of the plaque.

Synergistic anti-plaque mixture with tetradecylamine and copper, iron,

A method and a composition for retarding plaque are disclosed. The composition includes a synergistic mixture of tetradecylamine in combination with aluminum and/or zinc, each of which may be used singly or in admixture in combination with the amine. The method generally includes applying a mixture of the tetradecylamine in combination with one or more of the above metals to the site of the plaque.

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Norwood, NJ, United States of America

Thomas W Ritchey