Tetracore, Inc.

Thomas W O'Brien

Jennifer L Aldrich

Beverly Lynn Mangold

The present invention is directed to diagnostic tools and therapies using antibodies toSpecifically, the present invention is directed to a-specific monoclonal antibody that binds to the EA1 antigen (corresponding to the eag gene) of the S-layer (surface layer) of spores. This monoclonal antibody may be used in a variety of applications, including to specifically detect and diagnosePreferably, antibodies are monoclonal and bind to a surface protein, such as EA1 protein, on the spores ofand not to spores of eitherorAntibodies can be incorporated into detection kits using, for example, colloidal particle based lateral flow detection system. Such detection kits can distinguish anthrax spores from non-pathogenic varieties of spores. In addition, the invention is directed toEA1 antigen and pharmaceuticals such as vaccines that can be used as therapeutics and to develop improved antibodies and detection methods.

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Fairfax Station, VA, United States of America

Thomas W O'Brien