Vanderbilt University

Other

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States Government As Represented by the Department of Veterans Affairs

University of Georgia Research Foundation, Inc.

Orgenesis Ltd.

Tamir Biotechnology, Inc.

Sulley, Jamie

Squiquera, Luis

Hodge, Thomas

Thomas W Hodge

Donald H Rubin

Anthony Sanchez

Jamie Sulley

Luis Squiquera

Natalie J McDonald

James Murray

Michael W Shaw

The present disclosure provides methods for prophylactically treating a subject for viral infections comprising topically administering a ranpirnase composition. The disclosure also provides compositions that could be used for prophylactic treatment.

Prophylactic protection against viral infections

The present invention relates to a protein, ADAM10, ADAM10 nucleic acid sequences and ADAM10 proteins encoded by these sequences that are involved in infection by one or more pathogen such as a virus, a parasite, a bacteria or a fungus or are otherwise associated with the life cycle of a pathogen.

ADAM10 and its uses related to infection

Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.

Cell lines and host nucleic acid sequences related to infectious disease

The disclosure describes a method of inhibiting TNF in subjects comprising administering a TNF inhibiting amount of an extract ofto a subject. In addition, the present disclosure provides a method of inhibiting TNF in a cell line comprising administering to the cell line a TNF inhibiting amount of an extract from. Finally, the disclosure provides a method of treating a TNF mediated disorder in a subject, comprising administering an effective amount of an extract ofto the subject.

Methods of inhibiting tumor necrosis factor

Growing community of inventors

Roswell, GA, United States of America

Thomas W Hodge