University of Pittsburgh

Other

Acell, Inc.

Thomas W Gilbert

Stephen Francis Badylak

Tim D Oury

Christopher M Hobson

Michelle Manni

Alejandro Nieponice

Ethan N Ungchusri

John Joseph Stankus

William Richard Wagner

Donald O Freytes

Jianjun Guan

Yuanpu Di

Nikhil Niraj Gheewala

Chandra M Valmikinathan

Brent Donald Young

Brent D Young

Nikhil N Gheewala

The invention disclosed herein is directed to a porous wound healing foam composition that is made from an extracellular matrix of a mammal, method of making, and method of using.

Porous foams derived from extracellular matrix, porous foam ECM medical devices, and methods of use and making thereof

Methods of decellularization of tissue, such as mammalian tissue, are provided, along with methods of making an extracellular matrix (ECM) preparation. Systems and apparatus useful in performing the methods are also provided.

Method and apparatus for decellularization of tissue

Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived material to the respiratory system of the subject effective to prevent, lessen or treat pulmonary fibrosis in a subject. Also provided is an apparatus for delivering the powdered ECM-derived material to a subject.

Biologic scaffold for prevention of pulmonary fibrosis

Methods of decellularization of tissue, such as mammalian tissue, through use of cyclical pressure changes are provided, along with methods of making an extracellular matrix (ECM) preparation.

Method for decellularization of tissue

Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.

Extracellular matrix based gastroesophageal junction reinforcement device

Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.

Biohybrid elastomeric scaffolds and methods of use thereof

A learning toy based upon the concept of design or pattern formation is disclosed. The toy is comprised of a tray having a transparent bottom and a plurality of blocks which are arrangeable in the tray to form a design or pattern. Each block is painted with a primary color on four of its surfaces while the fifth surface of the block is painted with two of the primary colors with the boundary therebetween being on a diagonal across the surface of the block and the sixth surface of the block is painted with the other two primary colors with the boundary therebetween being on a diagonal across the surface of the block. When the blocks are arranged in the tray to form a design or pattern, a juxtaposition of dark and light colors is created on the top surface of the blocks and an &ldquo;opposite&rdquo; design or pattern is formed on the bottom surfaces of the blocks which can be viewed through the transparent bottom surface of the tray.

Growing community of inventors

Pittsburgh, PA, United States of America

Thomas W Gilbert