The Penn State Research Foundation

University of Michigan

The Pennsylvania Research Corporation

Thomas W Gardner

Chad E Reiter

Theodore M Hollis

Lauro V Ojeda

Jeffrey M Sundstrom

Minghui Huang

Anant Bhamri

Russ Miller

Hakan Demirci

Peter Nguyen

Justin T Holmer

Alan Cruz

A device comprising a syringe comprising a plunger and a barrel having a longitudinal axis and a sample collection volume. The device further comprises a needle hub including an attachment device for connection with the syringe, and a syringe support connected to the needle hub. A needle is connected to the needle hub, the needle having a lumen. An internal needle is at least partially positioned within the lumen of the needle. The device further includes a motor that rotationally moves the internal needle within the needle. The needle has a first opening formed in a side of the needle, and the internal needle has a second opening formed in a side of the internal needle; and wherein material is allowed to enter when the second opening is aligned with the first opening, and wherein the material is cut when the second opening rotates past the first opening.

Devices, systems, and methods for biological sample collection

This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes for treatment of nerve-related vision disorders such as diabetic retinopathy, and formulations useful in the practice of the disclosed methods.

Methods of treating nerve-related vision disorders by an insulinomimetic agent

Method of treating a nerve-related vision disorder in a non-diabetic subject

Periocular drug delivery for diabetic retinopathy

A method for treating and preventing retinopathy and for treating and preventing other small vessel complications associated with diabetes which comprises administering a therapeutically effective amount of an antihistamine or a pharmaceutically acceptable derivative thereof to a mammal having retinopathy or other small vessel complications associated with diabetes.

Method for treating retinopathy and other small vessel disorders

Growing community of inventors

Hummelstown, PA, United States of America

Thomas W Gardner