Dow Agrosciences LLC

Thomas V Worden

Raymond C Yao

Laura Lee Karr

Jeffrey Ryan Gilbert

Paul Richard Graupner

Paul Lewer

Donald R Hahn

Dennis W Norton

Gary D Crouse

Thomas Clarence Sparks

Carl Vincent DeAmicis

Herbert A Kirst

James Michael Gifford

Vidyadhar Babu Hegde

Lawrence C Creemer

Peter Biagio Anzeveno

Michael John Ricks

Joe Raymond Schoonover

Brian R Thoreen

Frederick Richard Green, Iii

Christopher J Hatton

Kevin L McLaren

Jacek G Martynow

Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.

Pesticidal macrolides

The compounds of the present invention are prepared directly or indirectly by modifying the compounds that are naturally produced from Saccharopolyspora spinosa. The compounds of the invention have been shown to have activity against insects and mites. The compounds are prepared by modifying the rhamnose sugar, modification of the forosamine sugar, or starting with pseuodoaglycone and then replacement with a nonsugar derivative or different sugar, modification of the 5,6,5-tricyclic and 12-membered macrocyclic lactone part of the compounds naturally produced or of the pseudoaglycone of the natural compounds.

Synthetic modification of Spinosyn compounds

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Indianapolis, IN, United States of America

Thomas V Worden