Harvard College

Stratec Consumables Gmb

Wen, Norman

Novak, Richard

Fernandez-alcon, Jose

Thomas Umundum

Alfred Paris

Donald Elliot Ingber

Daniel Levner

Christopher David Hinojosa

Geraldine A Hamilton

Norman Wen

Jose Fernandez-Alcon

Richard Novak

Remi Villenave

Guy Thompson

Georg Bauer

Karel Domansky

Kambez Hajipouran Benam

Wolfgang Reiter

Thomas Buttinger

Daniel Horner

Ii Guy Thompson

An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Organomimetic devices and methods of use and manufacturing thereof

A microfluidic flow controller comprising a substrate having formations defining two or more fluid channels having channel fluid ports which are open at an outer surface of the substrate; and a flexible layer having formations defining a fluid channel which, when the flexible layer is positioned over the substrate so as to cover at least the channel fluid ports, provides a fluid communication path between the channel fluid ports but which, when a force is applied to press the flexible layer towards the substrate, deforms so as to inhibit fluid communication between the channel fluid ports.

Microfluidic flow control and device

Growing community of inventors

Henndorf, Austria

Thomas Umundum