Forschungszentrum Julich Gmbh

Thomas Tierling

Christian Wandrey

Udo Kragl

Kurt Hamacher

Andreas Liese

Heinz Hubert Coenen

Juliane Beliczey

Furanosides or pyranosides can be reacted with pyruvate and converted into sialic acids in good yields by an enzymatic synthesis, using a suitable aldolase, where the concentration of aldolase, per 50 mM of pyruvate, is 1 to 2,500 U*/ml. For example, 3-fluoroneuraminic acid and other 3,3-didesoxy-3-fluorononulopyranosonic acid derivatives can be prepared in this manner. The F-atom in the resulting sialic acid (which can be F or F and F) provides a label which makes possible studies of mammalian physiology and diagnosis of mammalian diseases.

Growing community of inventors

Kö'ln, Germany

Thomas Tierling