Leland Stanford Junior University

Thomas T Lee

Richard Neil Zare

Rajeev Dadoo

An electrophoretic or chromatographic separation capillary containing a fluid or gel defines a bore therein through which a sample migrates and separates into components. The tube has a side wall defining a passage therein. A substance is introduced into the capillary through the pasage by means of gravity, pressure or electroosmosis. The substance introduced changes the electroosmotic flow rate of the fluid in the capillary tube. The electroosmotic flow rate of the fluid in the capillary tube can be monitored by introducing a compound through the passage and detecting the concentration of the compound. Information on the flow rate can be used in a feedback action to control the flow rate, such as to keep it constant.

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Palo Alto, CA, United States of America

Thomas T Lee