Cellectis

Medicago Inc.

Cellectis S.a.

Thomas Stoddard

Daniel F Voytas

Feng Zhang

Luc Mathis

Marc-Andre D'Aoust

Jin Li

Song Luo

William Haun

Benjamin Clasen

Marc-Andre D'aoust

Materials and methods are provided for making plants (e.g.,varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Mutantplant or cell with reduced XylT and FucT

Method for making nicotiana plants with mutations in XylT and FucT alleles using rare-cutting endonucleases

Materials and methods for genome engineering through transient expression of a targeted nuclease are described herein. For example, the methods described herein can include introducing into a cell a messenger RNA (mRNA) that encodes a nuclease targeted to a selected sequence within the cell, where the stability of the mRNA is modified by the addition of untranslated regions (UTRs).

Modifying messenger RNA stability in plant transformations

Materials and methods are provided for makingvarieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.

Potatoes with reduced cold-induced sweetening

Growing community of inventors

St. Louis Park, MN, United States of America

Thomas Stoddard