Bayer Animal Health Gmbh

Elanco Animal Health Gmbh

Intervet Inc.

Bayal Animal Health Gmbh

Thomas Simon Ilg

Hans-Georg Schwarz

Daniel Kulke

Wei Zhuang

Nils Griebenow

Walter Hübsch

Ulrich Görgens

Adeline Köhler

Claudia Böhm

Johannes Köbberling

Claudia Welz

Kirsten Börngen

Maike Hink

Bernd Alig

Niels Lindner

Iring Heisler

Werner Hallenbach

Carla Christina Schrier

Ulrich Ebbinghaus-Kintscher

Martin Adamczewski

Klaus Raming

Adeline Koehler

Walter Huebsch

Jaap Kool

Dirk Nennstiel

Nils Griebnow

Isa Jana Irina Janssen

Johannes Kobberling

Claudia Bohm

Walter Hubsch

Adeline Kohler

Kirsten Borngen

Zhuang Wei

Adeline KÖHLER

The present invention relates to novel compounds of general formula (I): withA being A1 or A: andin which T, X, Y, Ro, R, Rand Rare as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Anthelmintic compounds

The present disclosure relates to immunostimulatory compositions that are effective in eliciting immune responses in avian species. More specifically, these immunostimulatory compositions comprise an immunomodulator composition and an immunostimulatory oligonucleotide that when administered.

Immunostimulatory compositions

Compositions and methods for stimulating toll-like receptor 9 (TLR9) are provided. More particularly, immunostimulatory oligonucleotides, methods of enhancing immunostimulatory properties of oligonucleotides, and methods of eliciting immune responses are disclosed herein.

Immunostimulatory oligonucleotides

The present invention covers new quinoline compounds of general formula (I), in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Quinoline derivatives

The present disclosure relates to immunostimulatory compositions that are effective in eliciting immune responses in avian species. More specifically, these immunostimulatory compositions comprise an immunomodulator composition and an immunostimulatory oligonucleotide that when administered stimulate toll-like receptor 21.

The present invention covers new quinoline compounds of general formula (I): in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Anthelmintic quinoline-3-carboxamide derivatives

The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R, R, R, R, R, Rand Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Azaquinoline derivatives

The present invention covers quinoline compounds of general formula (I), in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Quinoline derivatives for treating infections with helminths

The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Bicyclic pyrazole derivatives

The present invention covers new quinoline compounds of general formula (I) in which A, R, R, R, R, R, R, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R, R, Rand Rare as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients. 

Pyrazolopyrimidine derivatives

The present invention relates to toll-like receptors, to cells comprising such toll-like receptors, to methods for the detection of immunostimulatory oligodeoxynucleotides wherein such methods use such toll-like receptors, to immunostimulatory oligodeoxynucleotides detected by use of this method, to the use of such immunostimulatory oligodeoxynucleotides in medicine and to vaccines comprising such immunostimulatory oligodeoxynucleotides.

Toll-like receptors

The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these method.

Growing community of inventors

Nieder-Olm, Germany

Thomas Simon Ilg