University of Bern

University of Washington

Otsuka Pharmaceutical Company, Limited

Universitât Bern

Thomas Seebeck

Joseph A Beavo

Scott Haydn Soderling

Natalie Glavas

Ana Rascon

Kewei Gong

Roya Zoraghi

Stefan Kunz

Andrea Johner

Yasmin Shakur

The present invention relates to novel amino acid and nucleic acid sequences of cyclic nucleotide-specific phosphodiesterases from the parasite. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the amino acid and nucleic acid sequences. The invention further relates to the use of these sequences, and of antibodies directed against these sequences, in the diagnosis and treatment of disorders related to the infection of, including the identification of compounds that form complexes with the polypeptides and nucleic acids of the present invention.

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The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

PDEs and uses thereof

Growing community of inventors

Ortschwaben, Switzerland

Thomas Seebeck