Scholar Rock, Inc.

Thomas Schurpf

Nagesh K Mahanthappa

Michelle Marie Straub

Abhishek Datta

Christopher Littlefield

Gregory John Carven

Justin W Jackson

Stefan Wawersik

Caitlin Stein

Matthew Salotto

Alan J Buckler

Andrew Avery

Allan Capili

Kevin B Dagbay

Christopher Chapron

George Coricor

Anthony Cooper

Susan Lin

Constance Martin

Frederick Streich, Jr

Julia McCreary

Adam Fogel

Katherine Jane Turner

Kimberly Kafadar Long

Mark Allen Farmer

Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.

Compositions and methods for growth factor modulation

Disclosed herein are inhibitors, such as antibodies, and antigen binding portions thereof, that selectively bind complexes of LTBP1-TGFβ1 and/or LTBP3-TGFβ1. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ1 activation, and treating subjects suffering from TGFβ1-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ1 inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGF-beta 1 and uses thereof

ProTGFβ1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGFβ1-GARP complex-selective antibodies or antigen-binding fragments, cells expressing proTGFβ1-GARP complex-selective antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled proTGFβ1-GARP complex-selective antibodies or antigen-binding fragments may be used to enhance an immune response in a subject, for example, against a cancer.

TGFβ antibodies, methods and uses

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Methods of screening for high-affinity, isoform-selective TGFβ1 inhibitors

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGFβ and uses thereof

Isoform-selective TGFB1 inhibitors and use thereof

Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-&#x3b2; superfamily of proteins.

Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF&#x3b2;1, LTBP1-TGF&#x3b2;1, LTBP3-TGF&#x3b2;1, and/or LRRC33-TGF&#x3b2;1. The application also provides methods of use of these immunoglobulins for, for example, inhibiting TGF&#x3b2;1 activity, and treating subjects suffering from TGF&#x3b2;1-related disorders, such as cancer and fibrosis.

TGF&#x3b2;1-binding immunoglobulins and use thereof

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGF&#x3b2; and/or LTBP3-TGF&#x3b2;. The application also provides methods of use of these inhibitors for, for example, inhibiting TGF&#x3b2; activation, and treating subjects suffering from TGF&#x3b2;-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGF&#x3b2; inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGF&#x3b2; and uses thereof

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF&#x3b2;1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Isoform-selective TGF&#x3b2;1 inhibitors and use thereof

Provided herein are antibodies that bind growth factor prodomain complexes, for example, growth factor prodomain complexes that include GDF-8 growth factor and GDF-8 prodomain. Also included are antibodies that bind growth factor prodomain complexes that have been altered by proteolytic processing.

Growing community of inventors

Cambridge, MA, United States of America

Thomas Schurpf