Scholar Rock, Inc.

Thomas Schurpf

Nagesh K Mahanthappa

Michelle Marie Straub

Abhishek Datta

Christopher Littlefield

Gregory John Carven

Justin W Jackson

Stefan Wawersik

Matthew Salotto

Caitlin Stein

Alan J Buckler

Andrew Avery

Kevin B Dagbay

Christopher Chapron

Allan Capili

Julia McCreary

Susan Lin

George Coricor

Frederick Streich, Jr

Anthony Cooper

Adam Fogel

Constance Martin

Katherine Jane Turner

Kimberly Kafadar Long

Anthony A Cooper

Mark Allen Farmer

Gregory J Carven

Alan Buckler

Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.

Compositions and methods for growth factor modulation

Disclosed herein are inhibitors, such as antibodies, and antigen binding portions thereof, that selectively bind complexes of LTBP1-TGFβ1 and/or LTBP3-TGFβ1. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ1 activation, and treating subjects suffering from TGFβ1-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ1 inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGF-beta 1 and uses thereof

ProTGFβ1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGFβ1-GARP complex-selective antibodies or antigen-binding fragments, cells expressing proTGFβ1-GARP complex-selective antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled proTGFβ1-GARP complex-selective antibodies or antigen-binding fragments may be used to enhance an immune response in a subject, for example, against a cancer.

TGFβ antibodies, methods and uses

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGFβ1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Methods of screening for high-affinity, isoform-selective TGFβ1 inhibitors

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGFβ and uses thereof

Isoform-selective TGFB1 inhibitors and use thereof

Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-&#x3b2; superfamily of proteins.

Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF&#x3b2;1, LTBP1-TGF&#x3b2;1, LTBP3-TGF&#x3b2;1, and/or LRRC33-TGF&#x3b2;1. The application also provides methods of use of these immunoglobulins for, for example, inhibiting TGF&#x3b2;1 activity, and treating subjects suffering from TGF&#x3b2;1-related disorders, such as cancer and fibrosis.

TGF&#x3b2;1-binding immunoglobulins and use thereof

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGF&#x3b2; and/or LTBP3-TGF&#x3b2;. The application also provides methods of use of these inhibitors for, for example, inhibiting TGF&#x3b2; activation, and treating subjects suffering from TGF&#x3b2;-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGF&#x3b2; inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGF&#x3b2; and uses thereof

Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF&#x3b2;1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Isoform-selective TGF&#x3b2;1 inhibitors and use thereof

Provided herein are antibodies that bind growth factor prodomain complexes, for example, growth factor prodomain complexes that include GDF-8 growth factor and GDF-8 prodomain. Also included are antibodies that bind growth factor prodomain complexes that have been altered by proteolytic processing.

Growing community of inventors

Cambridge, MA, United States of America

Thomas Schurpf