Abbott Gmbh & Co Kg

Thomas Schultz

Liliane Unger

Andreas Haupt

Wilfried Martin Braje

Karla Drescher

Sean Colm Turner

Udo Lange

Karsten M Wicke

Mario Mezler

Matthias Mayrer

The present invention relates to compounds of formula (I) wherein A is C-C-alkyl, C-C-haloalkyl, C-C-hydroxyalkyl, C-C-alkenyl, C-C-halo-alkenyl, C-C-cycloalkyl, aryl-C-C-alkyl, aryl-C-C-alkenyl, aryl or hetaryl;is a single or double bond; Xand Xare N, CR, NRor CRR; R, Rand Rare H, halogen, CN, NO, C-C-alkyl, C-C-alkoxy, C-C-alkylcarbonyl, etc. or two geminal radicals Rand Rtogether with the carbon atom to which they are bound may form a carbonyl group or a 3- to 6-membered carbocyclic or heterocyclic spiro-annulated ring; Ris hydrogen, C-C-alkyl, C-C-alkylcarbonyl, C-C-haloalkyl, etc.; or two vicinal radicals R, R, Ror Rtogether with Xand Xform a five- or six-membered carbocyclic or heterocyclic fused ring; Y, Yand Yare N or CR; Ris H, halogen, CN, NO, C-C-alkyl, C-C-alkoxy, C-C-alkylcarbonyl, C-C-haloalkyl, etc.; wherein a maximum of 3 of the radicals X, X, Y, Yand Yare selected from NRand N; Ris hydrogen, C-C-alkyl, C-C-hydroxyalkyl, C-C-haloalkyl, etc.; Ris C-C-alkyl or C-C-haloalkyl; n is 0, 1 or 2; physiologically tolerated acid addition salts and the N-oxides thereof, pharmaceutical composition comprising them, a method for treating medical disorders selected from diseases of the central nervous system, addiction diseases or obesity, said method comprising administering an effective amount of such compounds to a subject in need and the use of such a compound for preparing a pharmaceutical compositions.

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Ludwigshafen, Germany

Thomas Schultz