Dakocytomation Denmark A/s

Faustus Forschungs Cie, Translational Cancer Research Gmbh

Thomas Scholzen

Johannes Gerdes

Claudia Wohlenberg

Rolf Knippers

Patricia Prilla

Elmar Endi

Johanna Suwinski

Margrit Kernbach Hahn

Bettina Baron-L&uuml;hr

The invention relates to the use of a carboxy-terminal fragment of the Ki-67 protein or of an active part, fragment or homologue thereof as a compound that can be used for intracellular transfer and for the introduction in and the release by the cells. The invention further relates to transfer compounds that contain the above-mentioned Ki-67 protein and to the vectors encoding the same. The invention also relates to corresponding pharmaceutical compositions and to the use of the transfer protein as an excipient or active agent in the treatment of diseases.

Transfer compounds, production and use thereof

The present invention relates to monoclonal antibodies against the human Mcm3 protein, hybridoma cell lines that produce such antibodies, procedures for the production and their use, pharmaceutical compositions comprising a monoclonal antibody according to the present invention, their use for the prevention and treating of certain diseases as well as methods relating to the prevention and treatment of diseases associated with Mcm3 expression. Monoclonal antibodies according to the invention detect and bind human Mcm3 monospecifically both in immunohistological and immunobiochemical detection systems. The process for the production of these monoclonal antibodies comprises an initial screening of excess hybridoma supernatant with immunobiochemical methods followed by a second screening of positive hybridoma by means of an immunohistochemical method.

Monoclonal antibodies against human protein Mcm3, process for their production, and their use

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Neritz, Germany

Thomas Scholzen