Novaliq Gmbh

Phenex Pharmaceuticals Ag

Thomas Schlüter

Sonja Krösser

Chiara Silvana Leo

Alice Meides

Bernhard Günther

Markus Beier

Christoph Steeneck

Olaf Kinzel

Gerald Kleymann

Frank Löscher

Claus Kremoser

Thomas Hoffmann

Hartmut Voss

Kirsten Eickhoff

Michael Albers

Sanja Perovic-Ottstadt

Daniela Willen

The invention provides ophthalmic compositions comprising about 0.1% (w/v) cyclosporine dissolved in 1-(perfluorobutyl)pentane for use in the topical treatment of dry eye disease and provides for treatment methods thereof. The invention further provides kits comprising such compositions.

Ophthalmic composition for treatment of dry eye disease

The present disclosure provides methods of treatment using ophthalmic compositions comprising semifluorinated alkanes for keratoconjunctivitis sicca and/or Meibomian gland dysfunction, which methods provide for the enrichment of an ophthalmic tissue in the semifluorinated alkane, and optionally methods of delayed release of the semifluorinated alkane from the enriched ophthalmic tissue to the surface of the cornea and/or conjunctiva, and/or to the Meibomian gland.

Opthalmic compositions comprising F6H8

The invention provides ophthalmic compositions comprising about 0.1 % (w/v) cyclosporine dissolved in 1-(perfluorobutyl)pentane for use in the topical treatment of dry eye disease. The invention further provides kits comprising such compositions for the same use.

The invention provides modulators for the orphan nuclear receptor ROR&#x3b3; and methods for treating ROR&#x3b3; mediated diseases by administrating these novel ROR&#x3b3; modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof. 

Compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR&#x3b3;, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune disease

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Heidelberg, Germany

Thomas Schlüter