Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Thomas Schlaubitz

Paul Federer

Daniel Bommer

Andreas Gisler

Marcel Kaeppeli

Roland Bernet

Raymond Ochsenbein

Guido Grueter

Pius Studer

Christian George

Guenter Tenzler

Torsten Burdack

Andreas Scholle

Thomas Meyer

Sven Ebert

Stefan Vollenweider

Reto Schorno

Urs Wittenwiler

Stefan Job

Siegfried Müller

The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in a microtiter plate format.

Thermocycling of a block comprising multiple sample

A heating device for heating a thermally fixable sealing cover disposed over the microplate adjacent the wells, a cooling device for actively cooling the microplate and a controller set up to control activity of the heating and cooling devices in a manner to heat the sealing cover so as to thermally fix it to the microplate and to actively cool the microplate so as to keep a temperature of the samples below a predefined temperature when heating the sealing cover. It further relates to a method for automatically sealing a microplate in which the thermally fusible sealing cover is disposed over the microplate, the sealing cover is heated to thermally fix it to the microplate and the microplate is actively cooled in a manner that a temperature of the liquid reaction mixtures is kept below a predefined temperature when heating the sealing cover.

Instrument and method for automatically heat-sealing a microplate

An assembly comprising a sample block, a heat sink and at least one electrodeposited thermoelectric element is disclosed. Further, an instrument and a method for performing a temperature-dependent reaction are disclosed.

Assembly, instrument for performing a temperature-dependent reaction and method for performing a temperature-dependent reaction in an assembly

An automated nucleic acid analysis method and analytical system are described comprising separate modules, wherein the air flow of any one of said modules is controlled and wherein at least the air flow between the module for isolation and purification of the analyte and the module for analysis of the analyte are separated.

Amplification system with spatial separation

Disclosed herein are methods for monitoring a thermoelectric heating and cooling device () of a system () for cycling liquid reaction mixtures through a series of temperature excursions, and such systems adapted to perform these methods. A first quantity being either an electric current or an electric voltage is applied to the heating and cooling device () or a portion () thereof (), and a second quantity being either the non-selected first quantity or temperature is measured to obtain a first test value. The selected first quantity is applied to another thermoelectric heating and cooling device () or another portion () of the first device (), and the second quantity is measured to obtain a second test value. Comparison of the first and second test values yields a monitoring value which is compared with a pre-defined threshold value to obtain a monitoring result.

System and methods for monitoring a thermoelectric heating and cooling device

The invention relates to a thermocycler module for heating and/or cooling of a thermocycling device comprising a thermal switch, a heating block and a heat sink. The thermal switch comprises a thermoconducting liquid, e.g. a magnetic fluid or a liquid metal, and a stimulating unit, e.g. a magnetic unit or a Lorentz-force unit, for moving the thermoconducting liquid. The movement of the thermoconducting liquid provides, in an on-state of the thermal switch, a thermal connection between the heating block and the heat sink.

Thermocycling device with a thermal switch comprising a magnetic or metal thermoconducting liquid and a stimulating unit

A rack for holding containers containing liquids used in clinical chemistry analyzers. The rack comprises

Rack for analyzer and analyzer comprising such a rack

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Meggen, Switzerland

Thomas Schlaubitz