Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Leibniz-institut Fuer Neue Materialien Gemeinnuetzige Gmbh

Borsig Process Heat Exchanger Gmbh

Other

Uhde Gmbh

Thyssenkrupp Uhde Gmbh

Institut Fuer Neue Materialien Gemeinnuetzige Gmbh

Ursapharm Arzneimittel Gmbh & Co. Kg

Institut F&uuml;r Neue Materialien Gem. Gmbh

Thomas Schiestel

Helmut Schmidt

Christoph Lesniak

Herwig Brunner

Andreas Jordan

Hermann Schirra

Günter Tovar

Klaus Pfizenmaier

Matthias Grell

Norbert Stroh

Steffen Rupp

Steffen Schirrmeister

Peter Scheurich

Bernd Langanke

Achim Weber

R&uuml;diger Nass

Detmar Buxmann

Nicole Hauser

Angela Hammer

Björn Hoting

Jürgen Schmucker

Thomas Mueller

Steffen Werth

Nicole Dinges

Mirjam Kilgus

A modular element having a high-temperature stable main body, including at least one metallic or ceramic plate, which has at least one through-going aperture for the insertion of a ceramic capillary membrane and at least one potting in the form of a sufficiently gas-tight and high-temperature stable joint between the metallic or ceramic plate and the ceramic capillary membrane. The through-going aperture of the metallic or ceramic plate having an extension for accommodating the sufficiently gas-tight and high-temperature stable joint on at least one side of the metallic or ceramic plate.

Method for potting ceramic capillary membranes

Composites comprising at least one hollow fiber of oxygen-transporting ceramic material, which is a ceramic material which conducts oxygen anions and electrons or a combination of ceramic material which conducts oxygen anions and a ceramic or nonceramic material which conducts electrons, with the outer surface of the hollow fiber being in contact with the outer surface of the same hollow fiber or another hollow fiber and the contact points being joined by sintering, are described. Further composites comprise at least one hollow fiber of oxygen-transporting ceramic material which is a ceramic material which conducts oxygen anions and electrons or a combination of ceramic material which conducts oxygen anions and ceramic or nonceramic material which conducts electrons and a connection element for the introduction or discharge of fluids at at least one end face, with hollow fibers and connection element being joined. The composites can be used for isolating oxygen from oxygen-containing gas mixtures or for carrying out oxidation reactions.

Composite ceramic hollow fibres method for production and use thereof

The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.

Nanoparticles comprising biologically active TNF which is immobilized on the same

A microbicidally coated article, especially a container, having on at least part of it a coating comprising an organically modified inorganic matrix comprising silver colloids which is obtainable by application of a coating composition comprising a) a hydrolysate or condensate based on at least one hydrolysable silane with at least one non-hydrolysable substituent and b) a silver compound to the surface of the article and treatment with heat and/or radiation to form the silver colloid coating. Articles coated in accordance with the invention are therefore particularly suitable for purposes of disinfection, preservation, cosmetic, pharmaceutical or medical purposes. Articles from the pharmaceutical or medical sector, especially containers for pharmaceuticals or articles or components which come into contact with the human body and are required to be free from germs, are preferred fields of application.

Object having a microbicide coating, method for the production thereof and use of the same

The present invention relates to an improved method for mass spectrometric analysis, in particular for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using nanoparticles, where an analyte is added to a nanoparticle suspension, and the suspension containing the bound analyte is then deposited directly on a MALDI sample carrier and investigated by mass spectrometry, and to nanoparticles suitable for this method.

Mass spectrometric analysis using nanoparticles

The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell&#x2014;and in so doing uncover the shells underneath&#x2014;but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.

Nanoscale particles having an iron oxide-containing core enveloped by at least two shells

Components are separated from liquid or gaseous media with the aid of a nanocomposite comprising nanoparticles in a matrix, wherein the liquid or gaseous medium is brought into contact with the nanocomposite in such a way that at least part of the components to be separated off is bound to the nanocomposite and the resulting laden nanocomposite is separated from the liquid or gaseous medium.

Method for separating components from liquid and gaseous media with nanocomposites

The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell&mdash;and in so doing uncover the shells underneath&mdash;but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.

A process for preparing an agglomerate-free suspension of nanosize iron-containing oxide particles coated in a stable manner comprises preparing an aqueous suspension of nanosize iron-containing oxide particles which are partially or completely in the form of agglomerates; adding a trialkoxysilane and a water-miscible polar organic solvent which has a boiling point at least 10&deg; C. higher than the boiling point of water; treating the resulting suspension with ultrasound until at least 70% of the particles present are in the range of &plusmn;20% of the average particle diameter; removing the water by distillation under the action of ultrasound; and separating the non-disintegrated agglomerates.

Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating

Growing community of inventors

Stuttgart, Germany

Thomas Schiestel