Amsilk Gmbh

Ludwig-Maximilians-Universitat München

Universität Bayreuth

Basf Se Corporation

Amsik Gmbh

Thomas Scheibel

Daniel Huemmerich

Gerhard Winter

Lin Romer

Ute Slotta

Julia Engert

Matthias Lucke

Christian Ackerschott

Andreas Bausch

Axel Leimer

Lin Römer

Aniela Heidebrecht

Martha Geffers

Lukas Eisoldt

Marcus Fehr

Burghard Liebmann

Mario Brands

Daniel Hümmerich

Martin Schwab

Ingrid Martin

Uri Gat

Jens Klein

Andreas Lammel

Markus Hofer

Julia Myschik

Felix Bauer

Sebastian Remmensee

Christian Freudiger

Arne Ptock

Sebastian Rammensee

The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.

Articles comprising a silk polypeptide for antigen delivery

The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.

Methods for producing high toughness silk fibres

The present invention relates to the use of a biopolymer for reducing the formation of a biofilm, preferably on a substrate, whereby the biopolymer is preferably a polypeptide, such as recombinant spider silk polypeptide. The present invention further relates to methods for producing a substrate which reduces the formation of a biofilm on a surface of said substrate.

Use of bipolymer for reducing the formation of a biofilm

The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibers, the thus produced silk protein spinning dope solution, methods for producing fibers using said silk protein spinning dope solution.

The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.

Silk particles for controlled and sustained delivery of compounds

The present invention relates to a biopolymer having excellent tensile strength, extensibility and toughness. The present invention further relates to a nucleic acid molecule encoding the biopolymer of the invention, a vector comprising the nucleic acid molecule of the invention and a non-human host transformed with the vector of the invention. Furthermore, the present invention relates to methods for producing a biopolymer of the invention and to foams, films, gels, coatings, particles, capsules, springs or nonwoven mats as well as fibers comprising or consisting of the biopolymer of the invention. The present invention also relates to a method of producing fibers and the biopolymer of the invention for use in medicine, agriculture, cosmetics as well as surface, paper, leather and/or textile processing.

Biopolymer having excellent tensile strength, extensibility and toughness

The present invention is directed to a method of producing nano- and microcapsules from spider silk proteins The invention is further directed to nano- or microcapsules obtainable by this method as well as pharmaceutical, cosmetical and food compositions containing same.

Method of producing nano- and microcapsules of spider silk protein

The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, nano fibrils, threads, etc.

Microfluidic device for controlled aggregation of spider silk

Methods of producing nano-and microcapsules of spider silk proteins

The invention relates to the use of amphiphilic self-assembling proteins for formulating poorly water-soluble effect substances.

Use of amphiphilic self-assembling proteins for formulating poorly water-soluble effect substances

The present invention is directed to proteins of natural origin and materials made therefrom, in particular to threads, fibers, foams and gels derived therefrom. The invention further provides the use of these proteins/threads and materials in the field of technology, biotechnology and/or medicine, in particular in the manufacture of wound closure or coverage systems, suture materials and in the manufacture of replacement materials, preferably artificial cartilage or tendon materials, as well as in other commercial applications.

Proteins of natural origin and materials made therefrom

The present invention is directed to recombinant spider silk proteins, nucleic acids, coding for these recombinant spider silk proteins, as well as hosts suitable for expressing those nucleic acids. Furthermore, the present invention is directed to a method of aggregation of spider silk proteins and the use of the proteins in the field of biotechnology and/or medicine and other industrial fields, in particular in the manufacture of automotive parts, in the aircraft construction, in the processing of textiles and leather, as well as in the manufacture and processing of paper and the like.

Recombinant spider silk proteins

Growing community of inventors

Bayreuth, Germany

Thomas Scheibel