Cme Telemetrix Inc.

Massachusetts Institute of Technology

Thomas Scecina

Theodore E Cadell

Romauld Pawluczyk

Michael S Feld

Romuald Pawluczyk

Wei-Chuan Shih

Martin Hunter

Annika Enejder

The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.

Raman spectroscopy for non-invasive glucose measurements

Described is a method for measuring the concentration of a blood constituent within a body part ( ) of a living subject which comprises irradiating a body part of the subject with a continuum of a broad spectrum of radiation in adjacent and near infrared range of the electomagnetic spectrum; collecting the band of radiation after the radiation has been directed onto the part; dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector ( ) the detector taking measurements of at least one of transmitted or reflected radiation from the collected radiation; and transferring the measurements to a processor ( ), and then measuring the same kind of absorbance or reflectance with respect to one or more a discrete wavelengths of radiation from the longer near infrared range and using the measurements to calculate the concentration of the constituent.

Method for determination of analytes using NIR, adjacent visible spectrum and discrete NIR wavelenths

Described is a method which uses spectral data simultaneously collected in a continuous array of discrete wavelength points of the visible spectrum adjacent to the infrared and near infrared part of the light spectrum. The spectral data is collected using a number of detectors with different sensitivity ranges. Some detectors may be sensitive to visible and possibly, to part of the near infrared portion of radiation. Spectral data from die infrared spectrum is collected with the infrared detectors, and are in some embodiments insensitive to the visible links.

Method for determination of analytes using near infrared, adjacent visible spectrum and an array of longer near infrared wavelengths

The present invention relates to a method of building instrument variation tolerance into calibration algorithms for spectroscopic devices for chemical composition analysis with spectroscopic methods. The method of the present invention is particularly suitable for blood glucose, cholesterol and other chemical components prediction based on near-infrared spectrophotometry measurements. A method includes developing a calibration algorithm on a first instrument; applying the calibration algorithm to a second instrument; calibrating the second instrument and adjusting the calibration algorithm to account for differences between the first instrument and the second instrument; and repeating the step of applying (above) in respect of (n) further instruments to provide a calibration algorithm which may then be used on other instruments. Methods are also provided that develop calibration algorithms by adding instrument variations, based on mathematical manipulation, of the spectral data collected on calibration instruments.

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Medfield, MA, United States of America

Thomas Scecina