The Rogosin Institute

Sepsicure, LLC

Thomas S Parker

Daniel M Levine

Albert L Rubin

Bruce R Gordon

Stuart D Saal

Sanford R Simon

The invention relates to a method for treating sepsis in subjects who exhibit serum albumin levels, and one of total cholesterol or HDL levels, above minimum threshold values. The method involves intravenous administration of an emulsion, which contains a phospholipid, a neutral lipid, and a cholate salt.

Method for treating sepsis in patients with albumin, cholesterol and HDL levels above minimum thresholds

Treatment and prophylaxis of endotoxin caused toxicity is disclosed. This is accomplished by administering phospholipid containing compositions to the subject. The compositions are protein and peptide free, and may contain triglycerides, or other polar or neutral lipids.

Methods and compositions useful in prophylaxis and therapy of endotoxin

Protein and peptide free compositions are described, which are useful in treating endotoxemia. The compositions contain a phospholipid and a neutral lipid, preferably phosphatidylcholine and triglyceride.

Protein and peptide free, neutral lipid and phospholipid containing

Compositions useful in prophylaxis and therapy of endotoxin related

Methods useful in endotoxin based therapy

Treatment and prophylaxis of endotoxin caused toxicity is disclosed. This is accomplished by administering a lipid into which the endotoxin of concern is associated, preferably together with a peptide which is not an apolipoprotein. Preferably, the two components are administered in the form of a reconstituted particle, although this is by no means required.

Methods useful in endotoxin prophylaxis and therapy

A reconstituted high density lipoprotein containing particle is disclosed. The particle is useful in removing excess lipid soluble material from a subject to which it is administered, as well as in delivery of lipid soluble pharmaceuticals to subjects or patients.

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Brooklyn, NY, United States of America

Thomas S Parker