University of Kentucky Research Foundation

Other

Thomas S Foster

Anwar A Hussain

Lewis W Dittert

Philip W Landfield

Eric M Blalock

Kuey-Chu Chen

A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and/or cognitive decline. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease.

Biomarkers for aging

The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack.

Novel method of administering aspirin and dosage forms containing same

A saw chain grinding machine (10) is provided for sharpening a cutter link (56) of a saw chain (24). A grinding wheel (20) is swingable into position for grinding. A chain carriage (48) then brings the cutter link (56) into engagement with the grinding wheel (20). The chain carriage (48) has a base portion (12) mounted to the machine with the base portion having a pair of upwardly extending vertical supports (72, 74). A guide bar (76) spans the distance between them. The carriage housing (49) is mounted to the guide bar (76) by a plurality of rollers (78, 80, 82, 84, 86, 88, 90, 92, 94) which permit the housing to freely roll along the bar. Movement of the housing (49) is controlled by a control cable (98) that is operable to move the housing and thus the cutter link against the grinding wheel (20).

Growing community of inventors

Nicholasville, KY, United States of America

Thomas S Foster