Millennium Pharmaceuticals Limited

Mcgill University

Thomas S Barnes

Christopher C Fraser

Douglas A Holtzman

John D Sharp

Susan J Kirst

Siegfried Hekimi

Bernard Lakowski

Jason Lemieux

The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

Methods of modulating the activity of TANGO332

TANGO 332 polypeptides

The invention relates to the identification of gro-1 gene and to demonstrate that the gro-1 gene is involved in the control of a central physiological clock. Also disclosed are four other genes located within the same operon as the gro-1 gene.

C. elegans gro-1 gene

Growing community of inventors

Boston, MA, United States of America

Thomas S Barnes