Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Other

Aeterna Zentaris Gmbh

Thomas Rudel

Thomas F Meyer

Daniel Butzke

Sigrid Goedert

Michael Dittrich

Ina Scheuerpflug

Jurgen Maier

Sandra Eickernjager

Thomas Schwan

Eckhard Fischer

Nikolaus Machuy

Krishnaraj Rajalingam

Roland Richard Ryll

Ina B&auml;rbel Scheuerpflug

Thomas Franz Ferdinand Meyer

The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hare

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The present invention relates to pharmaceutical compositions comprising inhibitors of Prohibitin (PHB) for the prevention or/and treatment of hyperproliferative disorders.

Prohibitin as target for cancer therapy

Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genusto human cells. Also described are the proteins encoded by these nucleic acid molecules and antibodies directed against them. Furthermore, pharmaceutical compositions, vaccines and diagnostic compositions containing the nucleic acid molecules, proteins and/or antibodies are described.

The present invention relates to novel proteins having cytotoxic activity derived from the sea hare

Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus Neisseria to human cells. Also described are the proteins encoded by these nucleic acid molecules and antibodies directed against them. Furthermore, pharmaceutical compositions, vaccines and diagnostic compositions containing the nucleic acid molecules, proteins and/or antibodies are described.

Nucleic acid molecules encoding proteins which impart the adhesion of neisseria cells to human cells

The invention relates to recombinant gene sequences for synthesizing a protein having the biological activity of the PilC protein. Furthermore, the invention relates to DNA recombinant methods for the production of proteins having the biological activity of the PilC protein as well as the tools of molecular biology needed therein. Besides, the invention relates to proteins having the biological activity of the PilC protein and its antibodies. Further embodiments of the invention are pharmaceutical compositions with a content of the mentioned proteins or antibodies. Preferably, these pharmaceutical compositions serve as vaccines for the immunization against pathogenic bacteria bearing type 4 pili. The invention also relates to kits for the detection of bacteria bearing type 4 pili or antibodies directed against them containing the mentioned proteins or antibodies. Finally, the invention relates to cellular receptors for bacteria bearing type 4 pili and analogues thereof.

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Berlin, Germany

Thomas Rudel