Miltenyi Biotec, Gmbh

Miltenyi Biotec B.v. Co., Kg

Thomas Rockel

Eugen Uhlmann

Stefan Miltenyi

Andreas Bosio

Christian Dose

Jennifer Brieden

Jonathan Fauerbach

Sven Ignatius

Jurgen Krieg

Veronika Gann

Eugen Ullmann

Romualdus Smicius

Veronika Rudolf

Romualdas Smicius

Ute Bissels

Andrea VÖLKEL

Jürgen Krieg

Systems and methods are described for analyzing a plurality of biological samples with a plurality of fluorescent reagents in an automated fashion. The system may include two optical systems, a fluorescence imaging system and an optical quenching system. These two systems may be placed laterally adjacent to one another, and generally beneath one of the wells of sample-containing microtiter plate. The biological sample contained therein may be stained with a series of fluorescent reagents, with the fluorescence quenched between stainings. By precise positioning of the sample with respect to the imaging system, the sample may be imaged with a plurality of serially applied reagents.

Automated analysis tool for biological specimens

The invention is directed to a method for detecting a target moiety in a sample of biological specimens by: Use of the method in fluorescence microscopy, flow cytometer, spectrofluorometry, cell separation, pathology or histology.

Method for photobleaching stained cells

The invention is directed to a method for detecting a target moiety in a sample of biological specimens by: The method is useful to identify target moieties on the biological specimens. The biological specimens detected by the conjugate can be subsequently removed from the sample.

Cell detection with conjugates having an enzymatically releasable detection moiety

Lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula (I), with Oligonucleotide an unmodified or modified nucleic acid of 2-1000 nucleotides in length R=a bond or a linker unit Y=OH, SH or NHR3 X and Z=independently O, S or NR3 R3=hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms R1. R2 branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the provisio that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bond Use of lipophilic oligonucleotide according to Formula I for drug discovery or for transfection of cells. 

Lipohillic oligonucleotide analogs

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Düsseldorf, Germany

Thomas Rockel