Astrazeneca Ab

Astrazenela UK Limited

Thomas Richard Simpson

James Woods

James Kang

Robert Toms Jacobs

Yan Li

Jeffrey Albert

Cristobal Alhambra

Gerard Koether

Ashokkumar Bhikkappa Shenvi

Eifion D Phillips

Rebecca Urbanek

James Jeffrey Folmer

Cyrus Ohnmacht

Hui-Fang Chang

Timothy Piser

Edward J Warawa

James Rosamond

Timothy Davenport

Keith John Herzog

Bruce Thomas Dembofsky

Christopher Becker

William Jackson Frazee

Richard Alan Keith

Bipinchandra Chaudhari

Jianxing Kang

Gajendran Sundarababu

Christopher Holmquist

Hui Xiong

Gerald M Koether

Gerard M Koether

Jeffrey S Albert

Compounds of Formula I wherein R, A, R, R, R, R, R, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Alkylsulphonamide quinolines

Compounds of Formula I wherein R, A, R, R, R, R, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Alkyl sulfoxide quinolines as NK-3 receptor ligands

Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, Rand Rare as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.

Nicotinic acetylcholine receptor ligands 101

Compounds of Formula II wherein R, A, R, R, R, R, R, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid &#x3b2; protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid &#x3b2;-protein production such as Alzheimer's disease 

Lactams and uses thereof

Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid &#x3b2; protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit &#x3b3; secretase and thereby inhibit the production of amyloid &#x3b2; protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. 

1,4-diazacycloheptane derivatives

Therapeutic heterocycles

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West Chester, PA, United States of America

Thomas Richard Simpson