Abbvie Inc.

Solvay Pharmaceuticals, Gmbh

Thomas Rebne

Jeremy Hemingway

Christoph L Gillum

David Andrew Parrott

Ji Zhou

Rajkumar V Conjeevaram

Sean E Mackey

Martin J Gibler

Mark A Bennett

Kenneth E Hogue

Kenneth R Waeber

Patrick A Harrell

Bradley A Clark

Raj Conjeevaram

Bradley Clark

A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands.

Sealing arrangement for syringe

An apparatus and method of delivering adjustable metered doses of a composition from a squeezable container. An embodiment of the apparatus is a metered dose dispenser including a body that includes an inlet channel with a first opening, an outlet channel with a second opening, and a dosing wheel seat. The dosing wheel seat is a cavity defined by the body. The dosing wheel seat communicates with the inlet channel, via the first opening, and with the outlet channel, via the second opening. The metered dose dispenser also includes a removable, rotatable dosing wheel is situated within the dosing wheel seat when the metered dose dispenser is in use. The dosing wheel includes a dosing channel, which may be aligned with the inlet channel and the outlet channel. A plunger is movably situated in the dosing channel, the plunger does not fit through either the first or second opening.

Metered dose dispenser

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Woodstock, GA, United States of America

Thomas Rebne