Neurocrine Biosciences, Inc.

Other

Thomas R Webb

James R McCarthy

Chen Chen

Terence J Moran

Charles Q Huang

Keith M Wilcoxen

Jeffrey Paul Whitten

Yun Feng Xie

John Y Ramphal

This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein Ris NRRor OR; Ris Calkyl, Calkyloxy or Calkylthio; Ris hydrogen, Calkyl, Calkylsulfonyl, Calkylsulfoxy or Calkylthio; Ris hydrogen, Calkyl, mono- or di(Ccycloalkyl)methyl, Ccycloalkyl, Calkenyl, hydroxyCalkyl, CalkylcarbonyloxyCalkyl or CalkyloxyCalkyl; Ris Calkyl, mono- or di(Ccycloalkyl)methyl, ACH, CalkyloxyCalkyl, hydroxyCalkyl, Calkenyl, thienylmethyl, furanylmethyl, CalkylthioCalkyl, morpholinyl, mono- or di(Calkyl)aminoCalkyl, di(Calkyl)amino, CalkylcarbonylCalkyl, Calkyl substituted with imidazolyl; or a radical of formula &#x2014;Alk&#x2014;O&#x2014;CO&#x2014;Ar; or Rand Rtaken together with the nitrogen atom to which they are attached may form an optionally substituted pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).

Pyrazolopyrimidines as CRF receptor antagonists

Thiophenopyrimidines

Amino substituted pyrimidines and triazines

This invention concerns compounds of formula

CRF antagonistic thiophenopyridines

CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in the treatment of a variety of disorders, including disorders associated with the hypersecretion of CRF.

CRF receptor antagonists and methods relating thereto

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Olivenhain, CA, United States of America

Thomas R Webb