Epitope Limited

Syntex (u.s.a.) Inc.

Thomas R Thieme

Nanette M Klimkow

Andrew S Goldstein

Peter H Nelson

Stefan H Unger

Stephen C Piacentini

Howard J Ringold

James Patrick Dunn

B Melina Cimler

Stefan Gavojdea

A method of assaying a preselected volume of sample on an chromatographic strip includes providing a sample receiving reservoir. This reservoir can receive a preselected volume of sample or a preselected volume of sample and reagent. The sample receiving reservoir has an overflow outlet. A moat is communicated to the overflow outlet of the sample receiving reservoir for receiving the sample or sample and reagent when the sample receiving reservoir is full. The mixed sample or sample and reagent fill the sample receiving reservoir, and discharge the excess sample through the overflow outlet to the moat. The sample receiving reservoir having the preselected volume of sample or sample and reagent is discharged on the chromatographic strip for assay. Provision is made for adding a density adding solute which is neutral to the chromatographic strip, the density adding solute occupying the sample receiving reservoir. As a consequence, dense sample first occupies the sample receiving reservoir with less dense excess sample being rejected.

Sample volume control for lateral flow chromatography

This invention relates to the use and composition of materials which, when added to oral fluid samples, make such samples suitable for use with microparticle-based immunoassays. In one embodiment, this invention provides a method of reducing false positives in assays for the detection of an analyte in an oral fluid sample. The method involves providing an oral fluid sample combined with a bile acid or salt where the bile acid or salt is present in a concentration sufficient to reduce the rate of occurrence of false positives in said oral fluid based immunoassays.

Reduction of false positives in oral-fluid based immunoassays

A device for obtaining oral fluid containing substances for testing. In one embodiment, the device includes a syringe having a plunger at the end of which an absorbent pad is attached. A test assembly containing the device is also disclosed.

Oral collection device and kit

An improved method for determining the presence of an analyte in an oral fluid sample. A portion of the sample is mixed or contacted with a chromogenic substrate effective to produce a colored product upon reaction with .alpha.-amylase present in the sample. After a selected reaction time, the reaction mixture is inspected to determine the level of such colored product produced. Production of a level of colored product above a selected threshold within the reaction time indicates that an effective volume of undiluted oral fluid sample has been collected which is sufficient to allow detection of the analyte. A device for use in the method is also disclosed.

Saliva assay method and device

Oral sample collection method

Oral collection device

The present invention is concerned with collecting immunoglobulins from the oral cavity for immunological testing. A rinse is used to collect a specimen having a high concentration of immunoglobulins. The specimen can be subjected to a basic immunological testing technique which can be used as a tool for screening a patient for diseases. A test kit is also provided for.

Oral rinse immunoglobulin collection kit for immunoassay and method

Compounds useful for treating inflammation, swelling and associated pain, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-3;

3- and 4-biphenyloxyaminoalkanes and related compounds as

Compounds useful for treating inflammation, pain and swelling, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Y and Z are each independently halo, alkyl or alkoxy;

9-anthryloxyaminoalkanes and related compounds as anti-inflammatory and

Compounds of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein; Y is halo, alkoxy, alkyl, or dialkylamino;

Naphthoxyalkylamines and related compounds as antiinflammatory agents

Compounds of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Z is S;

Growing community of inventors

Independence, OR, United States of America

Thomas R Thieme