The Medicines Company

Melinta Therapeutics, Inc.

Thomas R Parr, Jr

Dario Lehoux

Gregory Moeck

Mark Harvey Wilcox

Simon Baines

Adel Rafai Far

Adam Belley

Eve Neesham-Grenon

Pierre Etienne

The present invention is directed to methods of inhibition, delay of formation, treatment, prophylaxis and/or prevention of infections caused by bacteria that exhibit tolerance to antimicrobial agents, including slow growing, stationary-phase and biofilm forming bacteria, through the use of glycopeptide antibiotics, such as oritavancin.

Methods of inhibiting and treating biofilms using glycopeptide antibiotics

The present invention is directed to methods of treating a bacterial infection in a subject through the administration of a therapeutically effective amount of a glycopeptide antibiotic to a subject having a bacterial infection. The effective amount of the glycopeptide antibiotic that is administered to the subject provides a fraction of the glycopeptide antibiotic administered to the subject bound to serum proteins within the subject and within a selected range.

Methods of treating bacterial infections using oritavancin

Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form ofandspores. Methods for the treatment, prophylaxis and prevention ofinfection and disease in animals, including humans, are described.

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Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against. Methods for the treatment, prophylaxis and prevention ofinfection and disease in animals, including humans, are described.

Use of oritavancin for prevention and treatment of anthrax

Method of inhibiting clostridium difficile by administration of oritavancin

Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against a wide range of bacteria. Methods for the treatment, prophylaxis and prevention of bacterial infection and disease in animals, including humans, using a single dose of oritavancin over the course of therapy, are described.

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Indianapolis, IN, United States of America

Thomas R Parr, Jr