Helsinn Healthcare Sa

Roche Palo Alto LLC

Biotie Therapies Corporation

Thomas R Malefyt

Roberta Cannella

Daniele Bonadeo

Andrew R Miksztal

Kathleen M Lee

Giorgio Calderari

Alberto Macciocchi

Christopher G Salentine

Riccardo Braglia

Enrico Braglia

Lesley Pickford

Carmine Panuccio

Mehdi Paborji

Stephen I Bandak

Leslie Pickford

The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose. The present invention is also directed to methods for treating diseases or conditions including Alzheimer's disease and/or Parkinson's disease, comprising administering to a patient in need thereof tablets regarding the same.

Compositions and methods for treating Alzheimer's disease and Parkinson's disease

The present invention provides a controlled-release composition containing tozadenant, at least one cellulose ether, and one or more pharmaceutically acceptable excipients. In the composition, the tozadenant is present in an amount ranging from about 30% (w/w) to about 65% (w/w) based on the total composition weight; and the cellulose ether is present in an amount sufficient to provide: not less than about 10% and not more than about 30% tozadenant dissolution over a 2-hour test period, not less than about 55% tozadenant dissolution over a 10-hour test period, and not less than about 80% tozadenant dissolution over a 16-hour test period. Use of the composition for treatment of Parkinson's disease is also described.

Controlled-release tozadenant formulations

The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.

Liquid pharmaceutical formulations of palonosetron

Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.

Benzothiazole derivatives

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Carmel Valley, CA, United States of America

Thomas R Malefyt