University of Minnesota

Other

Thomas R Hoye

Kevin H Mayo

Xuemei Chen

Zhixiong Ye

Lushi Tan

Christopher Ward Macosko

Jayanth Panyam

Grant W Fahnhorst

Jizhou Wang

Patrick H Willoughby

Carolee Flader-Lavey

Carolee Flader Lavey

Ashok Pehere

Adam Wohl

Vadims Dvornikovs

Dawen Niu

Lance A Vrieze

Brian P Woods

Shu Xu

Xuemei Cheri

Peter W Sorensen

Nicolas Ball-Jones

Beeraiah Baire

Jared M Fine

Monomers, polymers, or oligomers formed therefrom and methods of forming or utilizing monomers of formula I where Ris a Cto Calkyl; and X is &#x2014;OH; &#x2014;OM where M is lithium (Li), sodium (Na), or potassium (K), NH, RNH, RNH, RNH, RNwhere Rcan independently be selected from alkyl, benzyl, and combinations thereof; &#x2014;ORwhere Rcan be a Cto Calkyl, 2-ethylhexyl, or a hydrocarbon moiety of bio-renewable alcohol or a hydrogenated derivative thereof; &#x2014;NRR, &#x2014;NR&#x2014;NRR, &#x2014;NR&#x2014;ORwhere Rand Rcan independently be H, a Cto Calkyl, or combinations thereof.

Monomers and polymers formed thereby

Compounds of formula III: and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates useful for preparing compounds of formula III and methods for preparing compounds and materials from compounds of formula III.

Compounds from renewable resources

The invention provides methods for cyclizing poly-yne compounds under mild conditions to provide cyclic compounds.

Cyclization methods

The invention provides silicate prodrugs comprising a therapeutic agent linked to one or more groups of formula (I): &#x2014;Si(OR)(I); wherein each R independently has any of the values defined herein, as well as nanoparticles comprising such compounds.

Taxane silicate prodrugs and nanoparticles

A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.

Calixarene-based peptide conformation mimetics, methods of use, and methods of making

Compounds that function as lamprey attractants and methods.

Structural, behavioral characterization, and synthesis of attractants for migratory lamprey

Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment of SEQ ID NO:8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a &#x3b2;-turn inducing scaffold bonded between the first and second amino acid sequences.

Partial peptide mimetics and methods

A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins

A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enzyme.

Synthesis of acetogenins

A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

A method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

Method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins

Activated isoquinolines and naphthalenes are disclosed which are useful to prepare korupensamines, michellamines and analogs thereof.

Growing community of inventors

Saint Paul, MN, United States of America

Thomas R Hoye