University of Rochester

Thomas R Gaborski

James McGrath

Christopher C Striemer

Philippe M Fauchet

Michael Bindschadler

Morton Ehrenberg

Ian M Schwartz

A process for forming a porous nanoscale membrane is described. The process involves applying a nanoscale film to one side of a substrate, where the nanoscale film includes a semiconductor material; masking an opposite side of the substrate; etching the substrate, beginning from the masked opposite side of the substrate and continuing until a passage is formed through the substrate, thereby exposing the film on both sides thereof to form a membrane; and then simultaneously forming a plurality of randomly spaced pores in the membrane. The resulting porous nanoscale membranes, characterized by substantially smooth surfaces, high pore densities, and high aspect ratio dimensions, can be used in filtration devices, microfluidic devices, fuel cell membranes, and as electron microscopy substrates.

Ultrathin porous nanoscale membranes, methods of making, and uses thereof

Disclosed is a device for co-culturing two or more populations of cells using ultrathin, porous membranes positioned between cell culture chambers. Multiple chamber devices and uses thereof are described, including the formation of in vitro tissue models for studying drug delivery, cell-cell interactions, and the activity of low abundance molecular species.

Cell culture devices having ultrathin porous membrane and uses thereof

The invention provides methods and compositions for using actin for making micro- and nano-scale structures, including masking of two-dimentsional surfaces and non-conductive three dimensional spacers.

Growing community of inventors

Pittsford, NY, United States of America

Thomas R Gaborski