Ligand Pharmaceuticals, Inc.

Thomas R Caferro

Lin Zhi

Robert Higuchi

James Patrick Edwards

Donald Karanewsky

Neelakandha S Mani

Barbara A Pio

Mark E Adams

Jyun-Hung Chen

Anthony W Thompson

Kristen Lee Arienti

Marquis L Cummings

Charlotte L F Deckhut

Penghui Chen

Mani Neelakandha

Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.

Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods

Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.

Androgen receptor modulator compounds and methods

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Holly Springs, NC, United States of America

Thomas R Caferro