Merrell Dow Pharmaceuticals

Aventis Pharma Limited

Thomas R Blohm

Michael R Angelastro

Philip M Weintraub

Joseph P Burkhart

Gary A Flynn

Philippe Bey

Cynthia A Gates

The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.

Method of using 4-amino-.DELTA..sup.4 -steroids in the treatment of

The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are inhibitors of 5.alpha.-reductase. The compounds are useful for treating DHT-mediated diseases.

4-amino-.DELTA.4-steroids and their use as 5.alpha.-reductase inhibitors

The present invention relates to a method for the inhibition of C.sub.17-20 lyase enzyme which comprises administering to a patient in need of such inhibition, an effective amount of certain 4-amino-17-(hydroxyalkyl or dihydroxyalkyl)steroids or their esters or ethers. Certain of the aminosteroids used in the process are novel compounds.

Aminosteroids in a method for inhibiting C17-20 lyase

4-amino-4-ene-steroids and their use as 5.alpha.-reductase inhibitors

The present invention relates to novel A-nor-steroid-3-carboxylic acid derivatives and to their use as inhibitors of mammalian 5.alpha.-reductase.

Novel A-nor-steroid-3-carboxylic acid derivatives

This invention is directed to 17.beta.-(cyclopropylamino)androstenes and also to a method for using such compounds in the treatment of androgen-dependent disorders. The compounds are prepared by the hydride reduction of an appropriate steroidal imine or enamine.

17.beta.-(cyclopropylamino)androstene derivatives

This invention is directed to 4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The compounds are prepared by the hydride reduction of an appropriate steroidal imine or enamine.

4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and

This invention is directed to 4-substituted 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ols and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The ethers are prepared by using the Simmons-Smith reaction and an appropriate vinyl ether.

4-substituted 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ol and

This invention is directed to 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The ethers are prepared by using the Simmons-Smith reaction and an appropriate vinyl ether.

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Madeira, OH, United States of America

Thomas R Blohm