Leland Stanford Junior University

Via Pharmaceuticals, Inc.

Thomas Quertermous

Euan A Ashley

Raymond Tabibiazar

Adeoye Y Olukotun

Jonathan A Mathy

Mary M Chen

George P Yang

Melisa Cooper

Methods and compositions are described enhancing bone density or formation, including for stabilizing bone grafts, bone repair, joint replacement, and cartilage repair that includes providing a composition including Del-1 locally to a site for enhancing bone density or formation, or to a culture or chondrocytes or multipotent chondrocyte precursor cells, whereby survival or differentiation of chondrocytes at the site is enhanced, thereby ultimately enhancing bone density or formation. Methods and compositions for stimulating hair regrowth are also provided.

Use of Del-1 in hair, bone and cartilage regeneration

The invention provides a method of treating or preventing heart failure or a disease or condition associated with heart failure comprising administering an effective dose of an apelin peptide or APJ receptor ligand to the subject. According to certain embodiments of the invention the apelin peptide is administered chronically. In certain embodiments of the invention the apelin peptide is administered in an amount effective to improve at least one hemodynamic parameter or prognostic variable for heart failure. Clinical conditions associated with heart failure include, but are not limited to, atherosclerosis, restenosis, ischemic cardiovascular diseases, idiopathic or viral cardiomyopathy, and the like.

Apelin and uses thereof

The method of treating patients be administering phenylalkyl N-hydroxurea derivatives for combating atherosclerotic plaque and cardiovascular diseases and compositions for this use.

Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque

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Stanford, CA, United States of America

Thomas Quertermous