Twincore, Zentrum Fur Experimentelle Und Klinische Infektionsforschung Gmbh

Medizinische Hochschule Hannover

Technische Universitát Dresden

Helmholtz-zentrum Fur Infektionsforschung Gmbh

Centre National De La Recherche Scientifique

Universitéde Strasbourg

Ruprecht-karls-universitat Heidelberg

Twincore Gmbh

Thomas Pietschmann

Heinrich Steinmetz

Brigitte Kunze

Elisabeth Davioud-Charvet

Sibylle Haid

Thomas Schulz

Martin Messerle

Mark Brönstrup

Don Antoine Lanfranchi

Hans-Peter Prochnow

Gesine Hansen

Daniel Todt

Richard Brown

Christine Laqmani-Goffinet

Martin Wetzke

Sergej Franz

Chris Lauber

Lars Kaderali

Dominic Howard Banda

Nv Suryanarayana Birudukota

Sebastian Blockus

Juliane Gentzsch

Christina Grethe

Svenja Sake

Jessica Rückert

Nicolas Menzel

Ralf Bartenschlager

Wolfgang Fischl

Xavier Benlloch-Martin

Mourad Elhabiri

The present invention pertains to a method for the identification of genetic variants that are associated with the severity of an infectious disease. The invention further pertains to a set of genetic factors associated with the severity of Human respiratory syncytial virus (HRSV) infection, for example in human infants. The genetic polymorphisms identified according to the present invention are for use in the diagnostic of infectious diseases and patient stratification in order to avoid or reduce the occurrence of fatal events during infection or to elect the most appropriate therapeutic approach to treat the disease.

Diagnostics and therapy for human respiratory syncytial virus

The present invention pertains to a non-human genetically modified animal with increased susceptibility to infection with a human virus. The invention suggests to genetically impair the expression of newly identified viral infection repression factors CD302, Cr11, Ndufc2, AW112010, Scarb2 and Zc3hav1, which markedly improves infection with human viruses in none-human hosts. Furthermore provided are methods for the generation of the animal of the invention, methods for increasing or reducing the susceptibility of a cell to viral infection, methods for screening novel modulators of viral infection as well as new therapy options for the treatment of viral diseases, in particular hepatitis C.

Repressors of viral infection

The present invention relates to novel labyrinthopeptin derivatives. These labyrinthopeptin derivatives are useful for the treatment of infectious diseases, such as an infectious disease caused by an infection with human respiratory syncytial virus (RSV), Kaposi sarcoma-associated herpesvirus (KSHV), cytomegalovirus (CMV/HCMV), dengue virus (DENV), chikungunya virus (CHIKV), tick-borne encephalitis virus (TBEV; FSME virus), vesicular stomatitis Indiana virus (VSV), zika virus (ZIKV) and/or hepatitis C virus (HCV). Said labyrinthopeptin derivatives are also useful for analyzing the mode of action of labyrinthopeptins. Also encompassed by the present invention are labyrinthopeptins for use in treating an infectious disease, in particular an infectious disease caused by an infection with any one of the viruses selected from RSV, KSHV, CMV, CHIKV, TBEV, VSV, ZIKV and HCV. The invention further relates to a combination of labyrinthopeptin A1 and A2 for use as a medicament, e.g. for treating an infectious disease caused by an infection with RSV, KSHV, CMV, DENV, CHIKV, TBEV, VSV, ZIKV and/or HCV.

Labyrinthopeptins as anti-viral agents

Growing community of inventors

Hannover, Germany

Thomas Pietschmann