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Medizinische Universitaet Graz

Schaupp, Lukas

Pieber, Thomas

Thomas Pieber

Lukas Schaupp

Werner Regittnig

Gerd Koehler

Martin Ellmerer

A device for delivery of glucose-regulating medication, particularly insulin, depending on the measured tissue glucose concentration, having a sensor for measuring the glucose concentration in tissue fluid, possibly a unit for removing fluid from subcutaneous tissue, as well as a container for the glucose-regulating medications, having a unit for subcutaneous delivery of the glucose-regulating medications, and having a unit connected to the glucose sensor for regulating the quantity of the glucose-regulating medication to be delivered depending on the measured tissue glucose concentrations. The device simulates the function of the natural pancreas and is constructed small and compact. The sensor for measuring the tissue glucose concentration or the unit for removing the tissue fluid is combined with the delivery unit for subcutaneous delivery of the glucose-regulating medication, particularly in a shared catheter, so that the measurement of the tissue glucose concentration is essentially performed at the location of the delivery of the glucose-regulating medication.

Device and method for delivery of a physiologically active substance depending on a measured physiological parameter

The invention relates to a method for measuring the concentration of substances in living organisms using microdialysis, whereby bodily fluid is mixed with a perfusate and passed through a membrane and a substance value is determined for the bodily fluid with the aid of a sensor unit. According to the invention, to allow for the limited transport through the membrane, so that the measured substance value differs from the actual substance value in the organism, a reference substance present in said organism with a known value is also measured after passing through the membrane and mixing with the perfusate and the actual substance value is determined, based on the quotient from the known reference substance value divided by the measured reference substance value, multiplied by the measured substance value.

Method for measuring the concentration of substances in living organisms using microdialysis and a device for carrying out said method

In a device ( ) for in-vivo measurements of quantities in living organisms that comprises a catheter-like tube ( ) receiving in a removable manner a setting needle ( ) provided for inserting the tube in the organism, with at least one aperture ( ) being provided in the wall of the tube ( ); and a sensor ( ) for detecting the quantity to be measured in the interior of the tube; the sensor ( ) is mounted on a separate oblong carrier ( ) whose cross sectional dimensions are smaller than those of the interior of the tube. After the setting needle ( ) has been pulled out of the tube ( ), the sensor can be inserted in said tube ( ).

Device for conducting in vivo measurements of quantities in living organisms

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Graz, Austria

Thomas Pieber