Cyanagen S.r.l.

Thomas Paul Jansen

Leopoldo Della Ciana

Norbert Gretz

Rossana Perciaccante

Lorenzo Biagini

Manuela Vargiolu

Marina Eleonora Vettraino

Giacomo Rodeghiero

Dario Foglietta

Tiziana Picascia

Srishti Vajpayee

Rossana Perciaccanate

A method for increasing the light emission produced by the chemiluminescent reaction of 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione, a peroxidase enzyme or a conjugate thereof, an enhancer, a co-enhancer and a peroxide oxidizer, wherein the enhancer is an anionic N-alkylphenothiazine and the co-enhancer is selected from a 4-dialkylaminopyridine or an N-azole, and

Ultra-sensitive chemiluminescent substrates for peroxidase

A kit for performing an assay for determining an analyte in a sample with an extended shelf-life, wherein the kit comprises a chemiluminescent cyclic dihydrazide, an enhancer, a co-enhancer, and a peroxide oxidizer. The kit is useful in blot assays and immunoassays for the detection of proteins and nucleic acid molecules.

Chemiluminescent substrates for peroxidase with extended shelf-life

The present invention describes novel 7-alkylamino-3-(thienyl) coumarin fluorescent dyes of formula (I)  These dyes are water soluble, can be excited by the 405 nm excitation source and exhibit a large Stokes shift (&#x2265;80 nm). Furthermore, the dyes possess a reactive group for the labeling of biomolecules or other analytes.

Coumarin dyes and conjugates thereof

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Granarolo dell'Emilia, Italy

Thomas Paul Jansen