Ucb Biopharma Sprl

Thomas Paul Cain

Zhaoning Zhu

John Robert Porter

Daniel Christopher Brookings

Julien Alistair Brown

Victoria Elizabeth Jackson

Matthew Duncan Selby

Jonathan Bentley

Laura Gleave

James Madden

Alexander Heifetz

Craig Johnstone

Deborah Leigh

Boris Kroeplien

Martin Clive Hutchings

James Andrew Johnson

James Thomas Reuberson

Fabien Claude Lecomte

Helen Tracey Horsley

Martin Alexander Lowe

Joanna Rachel Quincey

Michael Alan Shaw

Anne Marie Foley

Ellen Olivia Gallimore

Praful Tulshi Chovatia

Laura Claire Reed

Anthony John Richardson

Sarah Emily Richardson

Laura Jane Gleave

Jonathan Mark Bentley

A series of imidazo[1,2-a]pyrazine derivatives, being potent modulators of human TNF&#x3b1; activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. The imidazo[1,2-a]pyrazine derivatives of the disclosure are of general formula 

Substituted imidazo[1,2-a]pyrazines as TNF activity modulators

A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. 

Imidazopyridine derivatives as modulators of TNF activity

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Thomas Paul Cain