Cellegy Pharmaceuticals Inc.

Osel, Inc.

Cellergy Pharmaceuticals, Inc.

Thomas P Parks

Jung-Chung Lee

Charles E Lee

Vivien Mak

Don R Baker

Angela Marcobal

Jørgen Skov Jensen

Thor Haahr

Trine Nilsen

Peter Humaidan

Niels Uldbjerg

This invention provides for a dry preserved formulation ofsuitable for administration to people as a pro-biotic or live biotherapeutic treatment where the formulation is stable, has high potency, and contains no animal-derived excipients.

High potency stable formulations of vaginal lactobacillus

Methods are described for increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived fromparagasseri,gasseri, and other bacterial strains. The bacteriocins are surprisingly advantageous as being selectively active againstbut relatively inactive against HO-producingspecies. Becauseis involved in the onset and maintenance of vaginal dysbiosis, selective removal of this bacterium from the vaginal microbiome treats or prevents conditions associated with vaginal dysbiosis, such as bacterial vaginosis and its sequelae.

Bacteriocins to improve vaginal colonization of hydrogen peroxide producing lactobacillus for female reproductive health

This invention provides for a method for improving the success rate of in vitro fertilization in women hosting abnormal vaginal microbiota. The method comprises the steps of: (i) selecting a woman suspected of hosting abnormal vaginal microbiota (AVM); (ii) administering to the woman a suitable antibiotic administered in an amount and duration effective to reduce the quantity of abnormal vaginal microbiota hosted by the woman; (iii) administering to the woman via vaginal administration an amount ofspecies in an amount sufficient to colonize the vaginal mucosa; and, (iv) transferring an embryo to the woman.

Use of vaginalfor improving the success rate of in vitro fertilization

High potency stable formulations of vaginal

The present invention provides store operated calcium influx inhibitor compounds, pharmaceutical compositions, and methods of use. The compounds are useful for treating an inflammatory disease or treating an inflammatory reaction. Preferably, compounds, compositions and methods of this invention are used for treatment of inflammatory skin, pulmonary, musculoskeletal, and gastrointestinal diseases, as well as autoimmune disorders, transplantation treatment, and osteoporosis.

Store operated calcium influx inhibitors and methods of use

Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O ) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr; -adrenergic antagonists, L-type Ca channel blockers, estrogens, ATP-sensitive K channel activators and smooth muscle relaxants are used.

Compositions and methods for the treatment of anorectal disorders

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San Mateo, CA, United States of America

Thomas P Parks