Centre National De La Recherche Scientifique

Alexion Pharmaceuticals, Inc.

Valorisation-recherche, Limited Partnership

Enobia Pharma Inc.

Other

Alexion Pharma Holding

Thomas P Loisel

Philippe Crine

Guy Boileau

Isabelle Lemire

Michel Bouvier

Arthur Donny Strosberg

Stefano Marullo

Pierre Boulanger

Pierre Leonard

Robert Heft

Hal Landy

A bone delivery conjugate having a structure selected from the group consisting of: A) X-D-Y-protein-Z; and B) Z-protein-Y-D-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dis a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.

Bone delivery conjugates and method of using same to target proteins to bone

The present invention describes a method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described herein, a model for studying the properties of these membrane receptors and an assay to screen molecules that are active on these membrane receptors.

Preparing membrane receptors from extracellular baculoviruses

Method of producing a recombinant membrane receptor protein by introducing a baculovirus expression vector encoding the membrane receptor protein into a host cell, culturing the resultant host cell for a sufficient time to permit expression of the membrane receptor protein and baculovirus viral particles and separating the cells from the viral particles. The baculovirus viral particles are then recovered.

Preparing membrane receptors from extracellular baciloviruses

Method for producing membrane receptors based on a baculovirus/insect cell system. The invention further includes the receptors produced by the method described herein, a model for studying the properties of these membrane receptors and an assay to screen molecules that are active on these membrane receptors.

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Montréal, Canada

Thomas P Loisel